Substituted pyridine methyl esters of cyclopropane carboxylic acids and their use as insecticides

ABSTRACT

Substituted pyridine methyl esters of cyclopropane carboxylic acids and the geometric and optical isomers thereof are prepared which correspond to the formula: ##STR1## wherein X independently represents alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, trifluoromethyl, 3,4-methylenedioxy, chloro, fluoro or bromo; n represents an integer of 0 to 2; Y represents oxygen or sulfur; R represents hydrogen, cyano or ethynyl and Z represents chloro, fluoro or bromo. These compounds have been found to exhibit a high degree of insecticidal activity and compositions containing said compounds are so employed.

CROSS-REFERENCE TO RELATED APPLICATION

This is a continuation-in-part of Application Ser. No. 777,188, filedMar. 14, 1977, now abandoned.

DESCRIPTION OF PRIOR ART

Various insecticidal compounds which are esters of cyclopropanecarboxylic acid are known. 3-(Fluorophenoxy)benzyl substitutedcyclopropanecarboxylates are taught in German Pat. No. 2,547,534.3-Phenoxybenzyl cyclopropane carboxylates are also taught in JapanesePat. No. 6,011,106. Phenoxy phenyl substituted cyclopropanecarboxylatesare taught as insecticides and acaricides in U.S. Pat. No. 3,961,070 andas tick control agents in South African Pat. No. 7,503,211 (based onU.S. Patent Application 487,417 filed Oct. 7, 1974). Other relatedsubstituted phenyl esters of cyclopropane carboxylic acids are taught inFrench Pat. No. 2,281,918. Various insecticidal 3-(dihalovinyloxy)benzylesters of cyclopropanecarboxylic acid are taught in German Pat. No.2,554,883 and ectoparasites are taught to be controlled by the use of3-phenoxybenzyl esters of spirocarboxylic acids in U.S. Pat. No.3,962,458. In addition, U.S. Pat. No. 3,979,519 teaches3-(2,2-dihalovinyloxy)benzyl 2-(2,2-dihalovinyl) 3,3-dialkylcyclopropanecarboxylates as insecticides.

SUMMARY OF THE INVENTION

The present invention is directed to substituted pyridine methyl estersof cyclopropane carboxylic acids and compositions containing said activecompounds and the use of such compositions in the kill and control ofvarious insect pests. The compounds of the present invention correspondto the formula ##STR2## wherein X independently represents alkyl of 1 to4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, trifluoromethyl,3,4-methylenedioxy, chloro, fluoro or bromo; n represents an integer of0 to 2; Y represents oxygen or sulfur; R represents hydrogen, cyano orethynyl and Z represents chloro, fluoro or bromo.

The compounds of the present invention can exist in several geometricisomeric forms as well as in several optically active isomeric forms,such as cis-configuration, trans-configuration, dextrorotatory andlevorotatory forms of each configuration and the various mixtures andracemates thereof are within the scope of the present invention.

In the present specification and claims, the term "alkyl of 1 to 4carbon atoms" is employed to designate straight chain alkyls of 1 to 4carbon atoms, branched chain alkyls of 3 or 4 carbon atoms and cyclicalkyls of 3 or 4 carbon atoms such as, for example, methyl, ethyl,propyl, butyl, isopropyl, isobutyl, secondary butyl, tertiary butyl,cyclopropyl and cyclobutyl.

In the present specification and claims, the terms "alkoxy of 1 to 4carbon atoms", "alkylthio of 1 to 4 carbon atoms" and "alkylsulfonyl of1 to 4 carbon atoms" are employed to designate alkoxy and alkylthiogroups of the formula

    --Y--loweralkyl

wherein Y is oxygen, sulfur or sulfonyl and alkyl is defined inhereinabove set forth for "alkyl of 1 to 4 carbon atoms".

The compounds of the present invention are generally high boilingliquids and possess low mammalian toxicity. The compounds aresubstantially insoluble in water and usually are moderately to highlysoluble in common organic solvents.

The compounds of the present invention can be prepared by the reactionof an appropriate substituted phenoxy or phenylthio pyridine methanol orsubstituted methanol and an appropriate2,2-dimethyl-3-(2,2-dihaloethenyl or vinyl)cyclopropane carboxylic acidhalide in the presence of a solvent and a hydrogen halide acceptor. Thereaction scheme is as follows: ##STR3##

In carrying out this reaction, the appropriate phenoxy or phenylthiopyridine methanol or substituted methanol and the appropriate2,2-dimethyl-3-(2,2-dihalovinyl)cyclopropane carboxylic acid halide aremixed together in substantially equimolar amounts, with the solvent,conveniently at room temperature. The hydrogen halide acceptor isthereafter added to the above mixture, with stirring. The mixture isstirred for from 0.1 to 24 hours and the mixture is then diluted withwater and extracted thoroughly with a conventional solvent such as, forexample, diethyl ether, hexane, methylene chloride or chloroform. Thesolvent extract is water washed, dried and concentrated under reducedpressure and if desired, purified by distillation or other conventionalmethods.

Representative solvents for use in carrying out this reaction includediethyl ether, methylene chloride, glyme and hexane.

Representative hydrogen halide acceptors include conventional bases suchas, for example, triethylamine, pyridine, dimethylaniline and theconventional alkali metal bases such as sodium hydroxide, potassiumhydroxide, sodium carbonate, potassium bicarbonate, sodium bicarbonateand the like.

In accordance with the present invention, it should be understood thatthe various geometric isomers as well as the mixed compound can beprepared by the procedures taught herein.

DESCRIPTION OF SOME PREFERRED EMBODIMENTS

The following examples illustrate the present invention and the mannerby which it can be practiced but, as such, should not be construed aslimitations upon the overall scope of the same.

EXAMPLE I 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester ##STR4##

To a cooled solution (10°-15° C.) of 2.0 grams (0.009 mole) ofcyano(6-phenoxy-2-pyridine)methanol and 2.0 grams (0.009 mole) of2,2-dimethyl-3-(2,2-dichloroethenyl)cyclopropane carboxylic acidchloride in 25 milliliters of anhydrous ether was added 1 milliliter oftriethylamine. A white precipitate separated out immediately. Thereaction mixture was stirred at room temperature for one-half (1/2)hour. The mixture was diluted with 50 milliliters of water and extractedthoroughly with ether. The ether extract was washed with water, driedover anhydrous magnesium sulfate and concentrated under vacuo to give3.4 grams of crude 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid:cyano(6-phenoxy-2-pyridinyl)methyl ester product as athick brown oil. This oil was purified by distillation under reducedpressure to give 1.8 grams of a light brown oil boiling at 190°-200° C.at 0.1-0.2 milliliters of mercury (mm). The oil had a refractive indexof n(25/D)=1.5264. The structure of the product was confirmed by itsnuclear magnetic resonance spectrum (NMR). Upon analysis, the productwas found to have carbon, hydrogen and nitrogen contents of 60.28, 4.47and 6.62 percent, respectively, as compared with the theoreticalcontents of 60.44, 4.35 and 6.71 percent respectively, as calculated forthe above compound. (Compound No. 1).

By following the preparative procedure outlined in Example I andemploying the appropriate cis- or trans-isomer of2,2-dimethyl-3-(2,2-dichloroethenyl)-cyclopropane carboxylic acidchloride, the following compounds were prepared.

Trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester having a refractive indexof n(25/D=1.5628 and carbon, hydrogen and nitrogen contents of 60.28,4.45 and 6.47 percent respectively, as compared with the theoreticalcontents of 60.44, 4.35 and 6.71 percent, respectively, as calculatedfor the above-named compound (Compound 1A); and

Cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester having a refractive indexof n(25/D)=1.5640 and carbon, hydrogen and nitrogen contents of 60.12,4.32 and 6.37 percent, respectively as compared with the theoreticalcontents of 60.44, 4.35 and 6.71 percent, respectively, as calculatedfor the above-named compound (Compound 1B).

The structure of both of the above compounds was confirmed by (NMR).

EXAMPLE II 2-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:(6-phenoxy-2-pyridinyl)methyl ester ##STR5##

A solution was prepared by dissolving 1.6 grams (0.008 mole) of6-(phenoxy)picolinalcohol and 1 milliliter of triethylamine in ˜25milliliters of dry ether. The solution was cooled to ˜10° and 1.93 grams(0.0085 mole) of 2,2-dimethyl-3-(2,2-dichloroethenyl)-cyclopropanecarboxylic acid chloride was added thereto, with agitation. The reactionmixture was allowed to sit at 10°-15° C. for ˜4 hours. The mixture waspoured into 50 milliliters of water and the organic phase, whichseparated, was removed and dried with ether. The ether was removed byevaporation and the 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid:(6-phenoxy-2-pyridinyl)methyl ester was recovered as apale ivory liquid in a yield of 1.7 grams by distillation under reducedpressure. The product had a refractive index of 1.5633 and the structureof the product was confirmed by NMR (Compound No. 2).

EXAMPLE III 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(3-fluorophenoxy)-2-pyridinyl)methyl ester ##STR6##

To a solution of 2.1 grams (0.0086 mole) ofcyano(6-(3-fluorophenoxy)-2-pyridine)methanol and 2.0 grams (0.0088mole) of 2,2-dimethyl-3-(2,2-dichloroethenyl)cyclopropane carboxylicacid chloride in 50 milliliters of anhydrous ether was added 3milliliters of triethylamine. A white precipitate separated outimmediately. The reaction mixture was stirred at room temperature forone-half (1/2) hour. The mixture was successively washed with water,dilute hydrochloric acid, dilute sodium hydroxide, dilute sodiumbisulfite, dilute hydrochloric acid and water and thereafter dried overanhydrous magnesium sulfate and concentrated under vacuo to give 3.5grams of crude 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid:cyano(6-(3-fluorophenoxy)-2-pyridinyl)methyl esterproduct as a residue. This residue was purified by distillation underreduced pressure to give 3.2 grams of a viscous yellow oil having arefractive index of n(25/D)=1.5538. The structure of the product wasconfirmed by its nuclear magnetic resonance spectrum (NMR). In addition,upon analysis, the product was found to have carbon, hydrogen andnitrogen contents of 57.91, 3.95 and 6.16 percent, respectively, ascompared with the theoretical contents of 57.94, 3.94 and 6.44 percent,respectively, as calculated for the above-named compound (Compound No.3).

EXAMPLE IV 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(3-methoxyphenoxy)-2-pyridinyl)methyl ester ##STR7##

To a solution of 3.0 grams (0.012 mole) ofcyano(6-(3-methoxyphenoxy)-2-pyridine)methanol and 2.8 grams (0.012mole) of 2,2-dimethyl-3-(2,2-dichloroethenyl)cyclopropane carboxylicacid chloride in 30 milliliters of anhydrous ether was added dropwise2.4 grams (0.024 mole) of triethylamine. A white precipitate separatedout immediately. The reaction mixture was stirred at room temperaturefor 2 hours. The mixture was diluted with 50 milliliters of water andextracted thoroughly with ether (2 portions of 50 milliliters each). Theether extract was washed with 100 milliliters of saturated sodiumbicarbonate solution, dried over anhydrous magnesium sulfate and thesolvent removed by evaporation under reduced pressure. The crude3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(3-methoxyphenoxy)-2-pyridinyl)methyl ester product wasrecovered as a residue and was a viscous golden oil. This oil waspurified by distillation under reduced pressure to give 4.8 grams of agolden oil having a refractive index of n(25/D)=1.5627. The structure ofthe product was confirmed by its nuclear magnetic resonance spectrum(NMR). Upon analysis, the product was found to have carbon, hydrogen andnitrogen contents of 58.82, 4.58 and 5.90 percent, respectively, ascompared with the theoretical contents of 59.07, 4.51 and 6.26 percent,respectively, as calculated for the above-named compound (Compound No.4).

EXAMPLE V 2-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:ethynyl(6-phenoxy-2-pyridinyl)methyl ester ##STR8##

A solution was prepared by bubbling into 100 milliliters oftetrahydrofuran, at 5°-7° C., purified acetylene for 15 minutes. To thissolution was added dropwise 10 milliliters of a 2.9 molar (29millimoles) solution of methyl magnesium bromide in 40 milliliters oftetrahydrofuran and the acetylene addition was continued for anadditional 1/2 hour. To this solution was added 5 grams (25 millimoles)of 6-(phenoxy)picolinaldehyde. The acetylene was stopped and the mixturewarmed to room temperature and held there for 3 hours. The reactionmixture was poured into ice water and the precipitate which formed wasredissolved by treatment of the mixture with dilute hydrochloric acid.The mixture was extracted with methylene chloride and the extract washedwith water, dried and the methylene chloride removed by evaporation. Theα-ethynyl-6-phenoxy-2-pyridine methanol product was recovered as aresidue in a yield of 7 grams. This product was not purified and wasmixed, at room temperature, with 100 milliliters of methylene chloride,6 grams (26 millimoles) of2,2-dimethyl-3-(2,2-dichloroethenyl)cyclopropane carboxylic acidchloride and 5 milliliters of triethylamine and stirred overnight. Thereaction mixture was sequentially washed with water, 5 percenthydrochloric acid, 5 percent sodium hydroxide, 5 percent sodiumbisulfate, 5 percent hydrochloric acid and water. The reaction mixturewas thereafter dried over magnesium sulfate and the methylene chlorideremoved by evaporation. The crude2-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:ethynyl(6-phenoxy-2-pyridinyl)methyl ester was recovered as aresidue and purified by elution twice through a chromatograph employinga 2.5 percent solution of acetone in hexane. The cis-isomer, a viscousyellow oil, was recovered as a first fraction in a yield of 1 gram andhad a refractive index of n(25/D)=1.5671. Upon analysis, the isomer wasfound to have carbon, hydrogen and nitrogen contents of 63.37, 4.69 and3.40 percent, respectively, as compared with the theoretical contents of63.47, 4.60 and 3.36 percent, respectively, as calculated for theabove-named compound. The trans-isomer was recovered as a secondfraction and solidified. This material was recrystallized from hexane asa white powder and was recovered in a yield of 1 gram. This productmelted at 106°-107° C. and upon analysis was found to have carbon,hydrogen and nitrogen contents of 63.49, 4.57 and 3.37 percentrespectively, as compared with the theoretical contents of 63.47, 4.60and 3.36 percent, respectively, as calculated for the above-namedstructure.

By following the preparative procedures as outlined in the aboveexamples, the following compounds set forth below in Table I areprepared.

                                      TABLE I                                     __________________________________________________________________________     ##STR9##                                                                                                 Refrac-                                                                       tive                                              Com-                    Molec-                                                                            Index                                                                             Analysis                                       No.pound                                                                          X.sub.n   Y                                                                               R     Z                                                                               Weightular                                                                        ##STR10##                                                                         CHNCalculated                                                                          CHNFound                            __________________________________________________________________________     5  3-CH.sub.3                                                                              O CN    Cl                                                                              43l.31                                                                            1.5610                                                                            61.264.676.50                                                                          61.374.816.58                         6  2-CH.sub.3                                                                              O CN    Cl                                                                              431.31                                                                            1.5602                                                                            61.264.676.50                                                                          61.424.836.51                         7  4-Cl      O CN    Cl                                                                              451.74                                                                            1.5687                                                                            55.833.796.20                                                                          55.633.835.97                         8  3-CF.sub.3                                                                              S CN    F 468.45                                                 9  3-CF.sub.3                                                                              S H     F 443.44                                                10  3-CF.sub.3                                                                              O CN    Cl                                                                              485.29                                                                            1.5311                                                                            54.433.515.77                                                                          54.193.635.49                        11  2-CF.sub.3                                                                              O CCH   Cl                                                                              484.31                                                12  4-F       O CN    Cl                                                                              435.28                                                                            1.5529                                                                            57.943.946.44                                                                          57.834.026.10                        13  4-CH.sub.3                                                                              O CN    Cl                                                                              431.31                                                                            1.5601                                                                            61.264.676.50                                                                          61.154.746.38                        14  4-C.sub.2 H.sub.5                                                                       O CN    Cl                                                                              445.34                                                                            1.5491                                                                            62.024.946.29                                                                          60.445.085.46                        15  3-C.sub.2 H.sub.5                                                                       O CN    Cl                                                                              445.34                                                                            1.5568                                                                            62.034.986.29                                                                          62.105.046.16                        16  2-C.sub.2 H.sub.5                                                                       S CCH   F 428.53                                                17  3-i-C.sub.3 H.sub.7                                                                     S H     Br                                                                              530.36                                                18  3-i-C.sub.3 H.sub.7                                                                     O CN    Cl                                                                              459.38                                                                            1.5545                                                                            62.755.276.10                                                                          62.855.345.61                        19  4-Br      O CN    Cl                                                                              460.74                                                                            1.5782                                                                            50.833.455.65                                                                          50.853.525.54                        20  2,4-Br.sub.2                                                                            S H     Br                                                                              655.06                                                21  --        S CN    Cl                                                                              433.36                                                                            1.5913                                                                            58.204.19 6.46                                                                         58.214.296.45                        22  4-OCH.sub.3                                                                             S H     Br                                                                              528.30                                                23  2-OCH.sub.3                                                                             O CN    F 412.40                                                24  3,4-methylenedioxy                                                                      O CN    Cl                                                                              459.33                                                                            1.5719                                                                            57.273.906.07                                                                          56.364.126.10                        25  2-OC.sub.4 H.sub.9                                                                      O CN    Cl                                                                              489.40                                                26  4-OC.sub.4 H.sub.9                                                                      S CN    Br                                                                              594.38                                                27  4-OC.sub.4 H.sub.9                                                                      O CN    Cl                                                                              489.40                                                                            1.5505                                                                            61.365.365.73                                                                          61.605.455.69                        28  3,5-(CH.sub.3).sub.2                                                                    O H     F 387.43                                                29  3,5-(CH.sub.3).sub.2                                                                    O CN    Cl                                                                              445.34                                                                            1.5573                                                                            62.034.986.29                                                                          62.095.015.97                        30  --        O CCH   Cl                                                                              416.31                                                31  2-F       O CN    Cl                                                                              435.28                                                                            1.5536                                                                            57.943.946.44                                                                          57.744.096.22                        32  4-SCH.sub.3                                                                             O CN    Cl                                                                              463.39                                                                            1.5870                                                                            57.024.326.05                                                                          57.064.475.92                        33  3,4-(CH.sub.3).sub.2                                                                    O CN    Cl                                                                              445.35                                                                            1.5608                                                                            62.034.986.29                                                                          62.145.066.01                        34  4-OCH.sub.3                                                                             O CN    Cl                                                                              447.32                                                                            1.5645                                                                            59.064.476.26                                                                          59.194.596.02                        35  3,5-(SCH.sub.3).sub.2                                                                   S CCH   F 491.65                                                36  3-CH.sub.3 ; 5-C.sub.4 H.sub.9                                                          O CN    Cl                                                                              455.43                                                37  3,5-(OC.sub.4 H.sub.9).sub.2                                                            O H     Cl                                                                              524.49                                                38  --        O CN    F 384.39                                                39  3-t-C.sub.4 H.sub.9                                                                     O CN    Cl                                                                              473.40                                                                            1.5548                                                                            63.415.535.92                                                                          63.205.585.55                        40  3-Br      O CN    Cl                                                                              496.20                                                                            1.5766                                                                            50.833.455.65                                                                          50.503.605.49                        41  2-OCH.sub.3                                                                             O CN    Cl                                                                              447.32                                                                            1.5621                                                                            59.074.516.26                                                                          58.484.575.98                        42  4-SC.sub.4 H.sub.9                                                                      O CN    Br                                                                              594.38                                                43  3-Cl      O CN    Cl                                                                              451.74                                                                            1.5673                                                                            55.833.796.20                                                                          55.713.845.98                        44  3,5-(CF.sub.3).sub.2                                                                    S CN    F 520.38                                                45  3,5-(CF.sub.3).sub.2                                                                    S H     F 511.44                                                46  3,5-(OC.sub.4 H.sub.9).sub.2                                                            O CN    Cl                                                                              561.51                                                47  2-CF.sub.3                                                                              O CCH   Br                                                                              641.22                                                48  3,4-Cl.sub.2                                                                            O CN    Cl                                                                              486.19                                                49  3-OCH.sub.3                                                                             O CN    Cl                                                                              447.32                                                                            1.5627                                                                            59.074.516.26                                                                          58.804.585.90                        50  4-SC.sub.4 H.sub.9                                                                      O CN    Cl                                                                              505.45                                                                            1.5718                                                                            59.405.195.54                                                                          59.475.215.01                         51*                                                                              4-SO.sub.2 CH.sub.3                                                                     O CN    Cl                                                                              495.39  53.344.075.66                                                                          53.854.425.06                        52  4-SO.sub.2 C.sub.4 H.sub.9                                                              O CN    Cl                                                                              537.47                                                53  2-Cl; 4-Br                                                                              S H     Br                                                                              575.15                                                54  2-Cl; 4-CF.sub.3                                                                        O CN    Cl                                                                              505.73                                                55  3-OCH.sub.3 ; 4-OC.sub.2 H.sub.5                                                        S CN    Cl                                                                              477.37                                                56  2-CH.sub.3 ; 4-Cl                                                                       O CN    Cl                                                                              453.76                                                                            1.5649                                                                            56.714.086.02                                                                          57.154.235.84                        57  3-CH.sub.3 ; 4-Cl                                                                       O CN    Cl                                                                              453.76                                                                            1.5720                                                                            56.714.086.02                                                                          56.934.05.72                         58  3,4-Cl.sub.2                                                                            O CN    Cl                                                                              486.19                                                                            1.5795                                                                            51.853.295.76                                                                          52.063.125.40                        59  3,5-Cl.sub.2                                                                            O CN    Cl                                                                              486.19                                                                            1.5785                                                                            51.853.295.76                                                                          52.073.065.34                        60  --        O CCH   Br                                                                              505.22                                                61  --        S CCH   Cl                                                                              432.37                                                62  4-Cl      O CCH   Cl                                                                              450.75                                                63  4-F       O CCH   Cl                                                                              434.30                                                64  4-F       S CCH   F 417.45                                                65  3-Cl      O CCH   Cl                                                                              450.75                                                66  4-OCH.sub.3                                                                             O CCH   Cl                                                                              446.33                                                67  4-CH.sub.3                                                                              O CCH   Cl                                                                              430.33                                                68  4-CH.sub.3                                                                              S CCH   Br                                                                              535.31                                                69  --        O H     Cl                                                                              392.29                                                70  --        O H     F 359.38                                                71  4-Cl      O H     Cl                                                                              426.73                                                72  4-F       O H     Cl                                                                              410.28                                                73  3-Cl      O H     Cl                                                                              426.73                                                74  4-OCH.sub.3                                                                             O H     Cl                                                                              399.26                                                75  4-CH.sub.3                                                                              O H     Cl                                                                              392.29                                                76  4-CH.sub.3                                                                              S H     Br                                                                              497.26                                                77  4-Cl      S H     F 409.89                                                78  3-Cl      S H     Br                                                                              531.71                                                79  4-F       S H     Br                                                                              515.25                                                80  4-OCH.sub.3                                                                             S H     F 382.41                                                __________________________________________________________________________     *Compound has melting point of 112°-114° C.                

PREPARATION OF STARTING MATERIALS

The 2,2-dimethyl-3-(2,2-dihaloethenyl)cyclopropane carboxylic acidhalides employed as starting materials in the preparation of the activecompounds of the present invention are well known compounds and aretaught in prior art references including J. Farkas et al., Chem. Listy.,52 688 (1958) (Chem. Abst. 52 13650 (1958)); U.S. Pat. No. 3,981,903. Inaddition, U.S. Pat. Nos. 3,979,519 and 3,981,903 teach the abovecarboxylic acids as the free acid. These acids can be converted to theacid halide by conventional procedures such as, for example, reacting ata temperature of from about room temperature to about 90° C. theappropriate 2,2-dimethyl-3-(2,2-dihaloethenyl)cyclopropane carboxylicacid with a thionyl halide such as thionyl chloride, thionyl bromide orthionyl fluoride or a phosphorus halide such as phosphorus trichlorideor phosphorus oxychloride in the presence of an organic solvent such asbenzene, hexane or a benzene-hexane mixture.

In addition, the cis- and trans-isomers of2,2-dimethyl-3-(2,2-dihaloethenyl)cyclopropane carboxylic acid halidesemployed as starting materials can be prepared by first separating thecorresponding free acid or ethyl ester of the above compound into therespective cis- and trans-isomers by conventional separation techniques,such as the one taught in Burt et al., Pesticide Science, 5, pages791-799, (1974), hydrolysis of the ester to the acid if such wasseparated and thereafter converting the acid to the acid halide astaught hereinabove.

The phenoxy or phenylthio pyridine methanol or substituted methanol usedas starting materials and corresponding to the formula ##STR11## whereinX, n, Y and R are as hereinbefore defined, can be prepared by a varietyof procedures depending upon the R substituent.

For those compounds of Formula II wherein R is hydrogen, the compoundscan be prepared by the reaction of an appropriate phenoxy or phenylthiopyridine carboxylic acid methyl ester of the formula ##STR12## whereinX, n, and Y are as hereinbefore defined with sodium borohydride in thepresence of a solvent.

In carrying out this reaction, the ester reactant is dissolved in asolvent such as methanol, or ethanol and the mixture cooled to atemperature of from about 0° to about 15° C. The sodium borohydride isthereafter added thereto while the temperature is maintained in theabove range. The mixture is maintained under these conditions until gasevolution is complete. Thereafter, the solvent is removed by evaporationand the residue taken up in a solvent such as, for example, diethylether. This mixture is water washed, washed with dilute hydrochloricacid (5-10%), dried and the solvent removed by evaporation to give thealcohol product. If desired, the product can be further purified.

EXAMPLE VI

6-(Phenoxy)picolinalcohol

EXAMPLE VI 6-(Phenoxy)picolinalcohol ##STR13##

A solution was prepared by dissolving 5.1 grams (0.022 mole) of6-(phenoxy)methyl picolinate in ˜250 milliliters of methanol. Thesolution was cooled to 10° C. and 7.6 grams (0.2 mole) of sodiumborohydride was added thereto portionwise over 1 hour while thetemperature was maintained at ˜30° C. Foaming occurred during theaddition and when it ceased, the methanol was removed by evaporation.The residue which remained was dissolved in ether and the resultingsolution water washed, washed with dilute hydrochloric acid, dried andthe solvent removed by evaporation. The tan oil which remained wasdistilled to give 1.6 grams of 6-(phenoxy)-picolinalcohol as anoff-white oil. The structure of the product was confirmed by NMR.

By following the preparative procedures as outlined in the aboveexamples, the following compounds set forth in Table II are prepared.

                  TABLE II                                                        ______________________________________                                         ##STR14##                                                                    X.sub.n                 Y                                                     ______________________________________                                        3-CH.sub.3              O                                                     2-CH.sub.3              O                                                     4-Cl                    O                                                     3-CF.sub.3              S                                                     2-CF.sub.3              S                                                     H                       S                                                     H                       O                                                     4-F                     O                                                     4-CH.sub.3              O                                                     4-C.sub.2 H.sub.5       O                                                     3-C.sub.2 H.sub.5       O                                                     2-C.sub.2 H.sub.5       S                                                     3-i-C.sub.3 H.sub.7     S                                                     4-Br                    O                                                     2,4-Br.sub.2            S                                                     4-OCH.sub.3             S                                                     2-OCH.sub.3             O                                                     3-OCH.sub.3             O                                                     3-CF.sub.3              O                                                     3-OCH.sub.3 ; 4-OC.sub.2 H.sub.5                                                                      S                                                     2-CF.sub.3              O                                                     3-i-C.sub.3 H.sub.7     S                                                     2-OC.sub.4 H.sub.9      O                                                     4-OC.sub.4 H.sub.9      S                                                     3-CH.sub.3 ; 5-C.sub.4 H.sub.9                                                                        O                                                     2-Cl; 4-Br              S                                                     2-Cl; 4-CF.sub.3        O                                                     3,5-(SCH.sub.3).sub.2   S                                                     4-SCH.sub.3             O                                                     4-SO.sub.3 CH.sub.3     O                                                     3,5-(OC.sub.4 H.sub.9).sub.2                                                                          O                                                     4-SO.sub.2 C.sub.4 H.sub.9                                                                            O                                                     3-C.sub.4 H.sub.9       O                                                     4-SC.sub.4 H.sub.9      O                                                     3,5-(CF.sub.3).sub.2    S                                                     ______________________________________                                    

the phenoxy or phenylthio pyridine carboxylic acid methyl esters of theformula ##STR15## wherein X, n, and Y are as hereinbefore defined andemployed as starting materials can be prepared by reacting anappropriate substituted phenoxy or phenyl mercaptan with a slight excessof the methyl ester of 6-chloro picolinic acid in the presence of a basesuch as an alkali metal hydride or lower alkoxide such as, for example,sodium, potassium, lithium or cesium hydride or sodium, potassium,lithium or cesium lower alkoxide of 1 to 4 carbon atoms (such as,methoxide, ethoxide, n-propoxide, i-propoxide, n-butoxide, sec-butoxideor t-butoxide), and a solvent such as, for example, diglyme,dimethylsulfoxide or dimethylformamide. This reaction can becharacterized as follows: ##STR16## wherein X, n, and Y are ashereinbefore defined and MA is an alkali metal hydride or alkoxide.

In carrying out this reaction, a solution of the phenyl mercaptan orphenol is dissolved in the solvent and the base is slowly added to asolution of the methyl ester dissolved in a solvent at a temperature offrom about 100° to about 120° C. After the addition is complete, thetemperature is slowly raised to about 130° to about 150° C. The reactionis usually complete in from about 1.5 to about 5.5 hours depending uponthe reactants. After the reaction is complete, the reaction mixture iscooled below 70° C. and poured over ice. The product comes down as asolid and is separated by filtration or as an oil and separated bydecantation. The crude product is taken up in diethyl ether, washed withwater and a base such as, for example, sodium bicarbonate and dried. Thesolvent is thereafter removed and if desired, the product can be furtherpurified by recrystallization from a solvent such as hexane, benzene,pentane, xylene or by distillation.

EXAMPLE VII 6-(6-Fluorophenoxy)methyl picolinate ##STR17##

To a solution of 37.7 grams (0.22 mole) of 6-chloromethyl picolinate in300 milliliters of diglyme was added dropwise a solution comprising 27.2grams (0.24 mole) of 3-fluorophenol, 27.2 grams (0.24 mole) of potassiumt-butoxide in 100 milliliters of diglyme. The addition was carried outat between 120°-130° C. The temperature was slowly raised to 145° C. andafter a 2.5 hour reaction time, the reaction was complete. The reactionmixture was cooled to ˜70° C. and poured over ice. The solid6-(6-fluorophenoxy)methyl picolinate which formed was filtered off anddissolved in ether. This solution was washed with water, dilute sodiumhydroxide and dried over anhydrous magnesium sulfate and the etherevaporated off. The product which remained as a residue was crystallizedfrom hexane and recovered in a yield of 25.4 grams melting at 54°-55° C.The structure of the compound was confirmed by NMR. Upon analysis, thecompound was found to have carbon, hydrogen and nitrogen contents of62.86, 4.28 and 5.53 percent, respectively, as compared with thetheoretical contents of 63.15, 4.08 and 5.67 percent, respectively,calculated for the above-named compound.

By following the preparative procedures as outlined above, employing theappropriate reactants, the following compounds set forth in Table IIIare prepared.

                  TABLE III                                                       ______________________________________                                         ##STR18##                                                                    X.sub.n              Y                                                        ______________________________________                                        3-CH.sub.3           O                                                        2-CH.sub.3           O                                                        H                    O                                                        H                    S                                                        4-Cl                 O                                                        3-OCH.sub.3          O                                                        4-SO.sub.2 CH.sub.3  O                                                        3-CF.sub.3           S                                                        2-CF.sub.3           S                                                        4-F                  O                                                        4-CH.sub.3           O                                                        4-C.sub.2 H.sub.5    O                                                        3-C.sub.2 H.sub.5    O                                                        2-C.sub.2 H.sub.5    S                                                        3-i-C.sub.3 H.sub.7  S                                                        4-Br                 O                                                        2,4-Br.sub.2         S                                                        4-OCH.sub.3          S                                                        2-OCH.sub.3          O                                                        3-OCH.sub.3 ; 4-OC.sub.2 H.sub.5                                                                   S                                                        3-CF.sub.3           O                                                        2-Cl; 4-CF.sub.3     O                                                        2-CF.sub.3           O                                                        3-i-C.sub.3 H.sub.7  S                                                        2-OC.sub.4 H.sub.9   O                                                        4-OC.sub.4 H.sub.9   S                                                        3,5-(SCH.sub.3).sub.2                                                                              S                                                        4-SCH.sub.3          O                                                        3,5-(OC.sub.4 H.sub.9).sub.2                                                                       O                                                        3-C.sub.4 H.sub.9    O                                                        4-SC.sub.4 H.sub.9   O                                                        2-Cl; 4-Br           S                                                        3-CH.sub.3 ; 5-C.sub.4 H.sub.9                                                                     O                                                        3,5-(CF.sub.3).sub.2 S                                                        ______________________________________                                    

for those compounds of Formula II wherein R is --C.tbd.CH, the compoundscan be prepared by reacting an appropriate 6-(phenoxy)-picolinaldehydewith lithium acetylide, lithium trimethylsilyl bromide or ethynylmagnesium bromide. The reaction can be characterized as follows:##STR19## wherein n, X and Y are as hereinbefore defined.

By following the preparative procedure outlined above, the followingcompounds set forth in Table IV can be prepared.

                  TABLE IV                                                        ______________________________________                                         ##STR20##                                                                    X.sub.n              Y                                                        ______________________________________                                        3-CH.sub.3           O                                                        2-CH.sub.3           O                                                        4-Cl                 O                                                        H                    S                                                        H                    O                                                        3-CF.sub.3           S                                                        2-CF.sub.3           S                                                        4-F                  O                                                        2-Cl; 4-Br           S                                                        4-CH.sub.3           O                                                        4-C.sub.2 H.sub.5    O                                                        3-C.sub.2 H.sub.5    O                                                        2-C.sub.2 H.sub.5    S                                                        3-i-C.sub.3 H.sub.7  S                                                        3-CH.sub.3 ; 5-C.sub.4 H.sub.9                                                                     O                                                        4-Br                 O                                                        2,4-Br.sub.2         S                                                        3-OCH.sub.3 ; 4-OC.sub.2 H.sub.5                                                                   S                                                        4-OCH.sub.3          S                                                        3-OCH.sub.3          O                                                        2-OCH.sub.3          O                                                        3-CF.sub.3           O                                                        2-CF.sub.3           O                                                        2-Cl; 4-CF.sub.3     O                                                        3-i-C.sub.3 H.sub.7  S                                                        2-OC.sub.4 H.sub.9   O                                                        4-OC.sub.4 H.sub.9   S                                                        3,5-(SCH.sub.3).sub.2                                                                              S                                                        4-SCH.sub.3          O                                                        3,5-(OC.sub.4 H.sub.9).sub.2                                                                       O                                                        3-C.sub.4 H.sub.9    O                                                        4-SC.sub.4 H.sub.9   O                                                        3,5-(CF.sub.3).sub.2 S                                                        ______________________________________                                    

for those compounds of Formula II wherein R is --CN, the compounds canbe prepared by the reaction, at room temperature, of an appropriate6-(phenoxy)picolinaldehyde of the formula ##STR21## wherein X, n and Yare as hereinbefore defined with an excess of an alkali metal cyanide inthe presence of an alkali metal bisulfite and water.

In carrying out this reaction, a solution of the aldehyde reactant, thebisulfite and water is reacted with a solution of the cyanide in water.The by-products precipitate out and are separated from the mixture. Theaqueous mixture which remains is solvent extracted with a solvent suchas benzene, pentane, ether, methylene chloride, hexane, or xylene, waterwashed and dried and the solvent removed by evaporation leaving thedesired product.

EXAMPLE VIII Cyano(6-(3-fluorophenoxy)-2-pyridine)-methanol (also knownas 6-(3-fluorophenoxy)α-hydroxy-2-pyridine acetonitrile) ##STR22##

A solution was prepared by mixing 10.6 grams (0.0488 mole) of6-(3-fluorophenoxy)picolin aldehyde and 5.6 grams (0.0537 mole) ofsodium bisulfite in 50 milliliters of water until a solution formed. Tothis solution was added 2.6 grams (0.0537 mole) of sodium cyanide in 50milliliters of water. A solid quickly formed and the aqueous mixturewhich remained was extracted with ether. The ether extract was washedwith a 10% sodium bisulfite solution followed by a water wash and driedover magnesium sulfate. The ether was thereafter removed by evaporation.The reaction product was crystallized from hexane to give 12.5 grams ofthe desired cyano(6-(6-fluorophenoxy)-2-pyridine)-methanol product whichmelted at 73°-74° C. Upon analysis, the product was found to havecarbon, hydrogen and nitrogen contents of 63.90, 3.85 and 11.32 percent,respectively, as compared with the theoretical contents of 63.93, 3.71and 11.47 percent, respectively, calculated for the above-namedcompound.

By following the preparative procedures as outlined in the aboveexample, the following compounds set forth in Table V are prepared.

                  TABLE V                                                         ______________________________________                                         ##STR23##                                                                    X.sub.n            Y                                                          ______________________________________                                        3-CH.sub.3         O                                                          2-CH.sub.3         O                                                          4-Cl               O                                                          3-CF.sub.3         S                                                          2-CF.sub.3         S                                                          4-F                O                                                          4-CH.sub.3         O                                                          H                  S                                                          H                  O                                                          2-Cl; 4-Br         S                                                          3-CH.sub.3 ; 5-C.sub.4 H.sub.9                                                                   O                                                          3-OCH.sub.3 ; 4-OC.sub.2 H.sub.5                                                                 S                                                          2-Cl; 4-CF.sub.3   O                                                          4-C.sub.2 H.sub.5  O                                                          3-C.sub.2 H.sub.5  O                                                          2-C.sub.2 H.sub.5  S                                                          3-i-C.sub.3 H.sub.7                                                                              S                                                          4-Br               O                                                          2,4-Br.sub.2       S                                                          4-OCH.sub.3        S                                                          3-OCH.sub.3        O                                                          2-OCH.sub.3        O                                                          3-CF.sub.3         O                                                          2-CF.sub.3         O                                                          3-i-C.sub.3 H.sub.7                                                                              S                                                          2-OC.sub.4 H.sub.9 O                                                          4-OC.sub.4 H.sub.9 S                                                          3,5-(SCH.sub.3).sub.2                                                                            S                                                          4-SCH.sub.3        O                                                          3,5-(OC.sub.4 H.sub.9).sub.2                                                                     O                                                          3-C.sub.4 H.sub.9  O                                                          4-C.sub.4 H.sub.9  O                                                          3,5-(CF.sub.3).sub.2                                                                             S                                                          ______________________________________                                    

the 6-(phenoxy)picolinaldehydes of the formula ##STR24## wherein X, nand Y are as hereinbefore defined which are employed as startingmaterials, can be prepared by reacting an appropriate phenoxy orphenylthio pyridine carboxylic acid methyl ester with an excess ofdiisobutyl aluminumhydride in the presence of a solvent such as,toluene, hexane or xylene. This reaction can be characterized asfollows: ##STR25## wherein X, n and Y are as hereinabove defined.

In carrying out this reaction, the ester reactant is mixed with thesolvent under an inert atmosphere and the mixture cooled to below minus(-) 50° C. The hydride is slowly added thereto at a temperature below-50° C. Upon completion of the reaction, an acetic acid-water-diethylether solution is mixed with the reaction mixture at about -50° C. andthe mixture heated slowly to room temperature. The insolubles areremoved by filtration and washed with a solvent such as diethyl ether.The filtrate is then followed by a water wash and a wash with sodiumbicarbonate and dried. The solvent is removed by evaporation and ifdesired, the product is further purified by recrystallization frompentane, hexane or benzene and dried.

EXAMPLE IX 6-(3-fluorophenoxy)picolinaldehyde ##STR26##

To a stirring mixture of 21.9 grams (0.0849 mole) of6-(3-fluorophenoxy)methyl picolinate in 150 milliliters of toluene at-50° C. and under a nitrogen atmosphere was slowly added 130 milliliters(0.0121 mole) of diisobutylaluminum hydride (20 percent in hexane) at-50° C. Upon completion of the reaction (as noted by gas-liquidchromatography), 150 milliliters of a solution made from 50 millilitersof acetic acid, 12 milliliters of water and 150 milliliters of ether wasslowly added to the reaction mixture at -50° C. The resulting solutionwas warmed slowly to room temperature. The mixture was thereafterfiltered and the filter cake washed thoroughly with ether and the ethersolution mixed with the filtrate. The filtrate mixture was washed withwater, a sodium bicarbonate solution, dried over anhydrous magnesiumsulfate and the ether was removed by evaporation. The6-(3-fluorophenoxy)-picolinaldehyde product remained as a residue andwas purified by crystallization from hexane. The product was recoveredin a yield of 13.9 grams and melted at 42°-43° C. The structure wasconfirmed by NMR. Upon analysis, the product was found to have carbon,hydrogen and nitrogen contents of 66.32, 3.92 and 6.21 percent,respectively, as compared with the theoretical contents of 66.36, 3.71and 6.45 percent, respectively, as calculated for the above-namedcompound.

By following the preparative procedures as outlined above, employing theappropriate picolinate reactant, the following compounds set forth inTable VI are prepared.

                  TABLE VI -                                                       ##STR27##                                                                    X.sub.n              Y                                                        ______________________________________                                        3-CH.sub.3           O                                                        2-CH.sub.3           O                                                        4-Cl                 O                                                        3-CF.sub.3           S                                                        2-CF.sub.3           S                                                        4-F                  O                                                        H                    S                                                        H                    O                                                        4-CH.sub.3           O                                                        4-C.sub.2 H.sub.5    O                                                        3-C.sub.2 H.sub.5    O                                                        2-C.sub.2 H.sub.5    S                                                        3-i-C.sub.3 H.sub.7  S                                                        4-Br                 O                                                        2,4-Br.sub.2         S                                                        2-Cl; 4-Br           S                                                        4-OCH.sub.3          S                                                        3-OCH.sub.3          O                                                        2-OCH.sub.3          O                                                        3-CF.sub.3           O                                                        2-CF.sub.3           O                                                        3-i-C.sub.3 H.sub.7  S                                                        2-OC.sub.4 H.sub.9   O                                                        4-OC.sub.4 H.sub.9   S                                                        3,5-(SCH.sub.3).sub.2                                                                              S                                                        4-SCH.sub.3          O                                                        4-SO.sub.2 CH.sub.3  O                                                        3,5-(OC.sub.4 H.sub.9).sub.2                                                                       O                                                        3-CH.sub.3 ; 5-C.sub.4 H.sub.9                                                                     O                                                        3-OCH.sub.3 ; 4-OC.sub.2 H.sub.5                                                                   S                                                        2-Cl; 4-CF.sub.3     O                                                        3-C.sub.4 H.sub.9    O                                                        4-SC.sub.4 H.sub.9   O                                                        3,5-(CF.sub.3).sub.2 S                                                        ______________________________________                                    

in accordance with the present invention, it has been discovered thatthe substituted pyridine methyl esters of cyclopropane carboxylic acidpossess insecticidal properties. The compounds have quick knockdownactivity and low persistence, as toxic residues, and have low mammaliantoxicity.

Because of the "quick knockdown", the subject compounds are particularlysuitable for the control, inside houses, barns, warehouses, publicbuildings, and the like, of pests, including cockroaches, such as theGerman cockroach, American cockroach, and brown-banded cockroach;beetles, such as the black-carpet beetle, confused flour beetle,saw-tooth grain beetle, and larder beetle; spiders, silverfish, bedbugs;fleas, such as those on bedding used by household pets, and flea larvae;mosquitos; boxelder bugs; spiders; mites; ants; centipedes; and flies,such as hornfly, stable fly and facefly and the common housefly. Thesubject compounds are highly effective for such indoor control of insectpests and thus are particularly adapted for such employment. Inaddition, the subject compounds are also useful for the control of liceand ticks and other insects parasitic to animals.

The new compounds of the present invention are very effective for thecontrol of the many insect pests found on the roots or aerial portionsof growing plants, including aphids, scale, mites, and chewing andsucking insects, such as leafhopper, Southern army worm, two-spottedspider mite, cotton aphid, cabbage looper, western spotted cucumberbeetle, bollworm, codling moth, beet armyworm, and tobacco budworm.

The subject compounds, when applied to plants, plant parts, and theirhabitats to protect the plants from the attack of insect pests, exhibitresidual control of the insects over only a relatively short period oftime thereby not having appreciable build-up in the environment.

In some procedures, the compounds can be vaporized or sprayed ordistributed as aerosols into the air, or onto surfaces in contact withthe air. In such applications, the compounds manifest the usefulproperties hereinbefore described.

The methods of the present invention comprise contacting an insect withan insecticidally effective or inactivating amount of one of thecompounds of the present invention.

The contacting can be effected by application of the compound to thehabitat of the insects. Representative habitats include soil, air,water, food, vegetation, inert objects, stored matter such as grains,other animal organisms, and the like. The inactivation can be lethal,immediately, or with delay, or can be a sub-lethal one in which theinactivated insect is not able to carry out one or more of its normallife processes. This latter situation prevails when one of the systemsof the insect, typically the nervous system, is seriously disturbed. Apreferred embodiment of the present invention comprises the employmentof the present method for the kill and control of insects; suchemployment gives excellent results, particularly in control of insectsthat have developed resistance against other pest-control substances.

The inactivation of an insect by the application of an insecticidallyeffective or inactivating amount of one of the presently claimedcompounds is critical to the method of the present invention. Thecompound can sometimes be employed in unmodified form. Frequently,however, for easier application, the compound is modified by theemployment with it of a pesticidal adjuvant or inert carrier therefor.Thus, for example, the present compounds are of very low solubility inwater but are relatively soluble in oils, including plant essentialoils. Therefore, the practical enjoyment of the beneficial utilities ofthe present compounds often requires that the compound be compositedwith one or more pesticidal adjuvant substances, and the resultingcompositions are comprehended within the present invention.

The compositions can be formulated in various forms, such asemulsifiable concentrates, wettable powders, flowable suspension dusts,granules, microencapsulated granules, fine granules, oil sprays,aerosols, heating fumigants (e.g. mosquito coils, electric mosquitokiller mat, etc.), fogging mists, non-heating fumigants and poisonousbaits and the adjuvant employed can be any one or a plurality ofmaterials including aromatic solvents, petroleum distillates, water, orother liquid carriers, propellant substances, surface-active dispersingagents, light absorbers, and finely divided carrier solids. In suchcompositions, the adjuvant cooperates with the compound so as to obtaina composition to facilitate the method of the present invention, and toobtain an improved result. The use of either a surface-active dispersingagent or a finely divided carrier solid and the use of both asurface-active dispersing agent and a finely divided carrier solid,simultaneously, constitute preferred embodiments of the method of thepresent invention. Another preferred embodiment of the present inventionis a composition comprising one or more of the presently claimedcompounds, an organic liquid as a solvent and carrier therefor, and apropellant material. Numerous other embodiments will become available tothose skilled in the art in view of the teachings set forth hereinbelow.

The exact concentration of the active compounds in a composition thereofwith an adjuvant therefor can vary; it is only necessary that the activecompounds be present in a sufficient amount so as to make possible theapplication of an insecticidally effective or inactivating dosage.Generally, for practical applications, the active compounds can bebroadly applied to insect pest organisms or their habitat incompositions containing from about 0.00001 percent to about 98 percentby weight of the active compound.

In the preparation of dust compositions, the product can be compoundedwith any of the finely divided carrier solids such as pyrophyllite,diatomaceous earth, gypsum and the like. In such operations, the finelydivided carrier is ground or mixed with one or more of the activecompounds, as active agent, or wetted with a solution of the activeagent in a volatile organic solvent. Similarly, dust compositionscontaining the active product can be similarly compounded from variousof the solid dispersing agents, such as fuller's earth, attapulgite andother clays. These dust compositions can be employed as treatingcompositions or can be employed as concentrates and subsequently dilutedwith additional solid dispersing agent or with pyrophyllite,diatomaceous earth, gypsum and the like to obtain the desired amount ofactive agent in a treating composition. Also, such dust compositions canbe dispersed in water, with or without the aid of surfactant, to formspray mixtures.

Further, one of the compounds or a dust concentrate compositioncontaining such compound can be incorporated in intimate mixture withsurface active dispersing agents such as ionic and nonionic emulsifyingagents to form spray concentrates. Such concentrates are readilydispersible in liquid carriers to form sprays containing the toxicant inany desired amount. The choice of dispersing agent and amount thereofemployed are determined by the ability of the agent to facilitate thedispersion of the concentrate in the liquid carrier to produce thedesired spray composition.

In the preparation of liquid compositions, the compounds of the presentinvention can be compounded with a suitable water-immiscible organicliquid and surface-active dispersing agent to produce an emulsifiableliquid concentrate which can be further diluted with water and oil toform spray mixtures in the form of oil-in-water emulsions. In suchcompositions, the carrier comprises an aqueous emulsion, that is, amixture of water-immiscible solvent, emulsifying agent and water.Preferred dispersing agents to be employed in these compositions areoil-soluble and include the non-ionic emulsifiers such as thepolyoxyethylene derivatives of sorbitan esters, complex ether alcoholsand the like. However, oil-soluble ionic emulsifying agents such asmahogany soaps can also be used. Suitable organic liquids to be employedin the compositions include petroleum oils and distillates, toluene,liquid halohydrocarbons and synthetic organic oils.

When operating in accordance with the present invention, the compound ora composition containing the compound is applied to the insects to becontrolled directly, or by means of application to a portion or portionsof their habitat in any convenient manner, for example, by means of handdusters or sprayers or by simple mixing with the food to be ingested bythe organisms. Application to the foliage of plants is convenientlycarried out with power dusters, boom sprayers and fog sprayers. In suchfoliar applications, the employed compositions should not contain anyappreciable amounts of any phytotoxic diluents. In large scaleoperations, dusts, or low-volume sprays can be applied from an airplane.The present invention also comprehends the employment of compositionscomprising one of the compounds, an adjuvant, and one or more otherbiologically active materials, such as insecticides, fungicides,miticides, bactericides, nematocides, and the like.

A preferred and especially convenient matter for the application of oneor more of the present products comprises the use of a self-pressurizedpack formulation which can be used, for example, as a space or surfacespray. Such a formulation can comprise one or more of the compounds, anorganic liquid as a solvent and vehicle therefor, and a propellantmaterial which can be a condensed and compressed gas or a substancewhich, at room temperature, is a gas under atmospheric pressure butwhich liquifies under superatomspheric pressure. Where the propellantmaterial is of the latter type, the self-pressurized pack formulation isoften spoken of as an aerosol. Representative propellants includepropane, butane, nitrogen, and the fluorinated hydrocarbons, such asdichlorodifluoromethane and trichlorofluoromethane. Generally, thepropellant constitutes from 25 to 95 percent by weight of the totalself-pressurized pack. As vehicle, there can be employed any liquid inwhich the desired amount of product is capable of being dispersed;preferred vehicles include petroleum distillates, kerosene, andmethylene chloride. The self-pressurized pack formulation can alsoinclude other materials, such as other biologically active agents orsynergists. For further discussion of the use of self-pressurized packformulations, see U.S. Pat. Nos. 1,892,750 and 2,321,023.

The compositions of the present invention will be illustrated in furtherdetail below with reference to the examples, but the kinds and mixingproportions of compounds and additives are not limited to those shown inthe examples but are variable within wide ranges. In the Examples setforth hereinafter, the compounds employed are referred to by thecompound number as herein above set forth. All parts are based on weightpercent of the total composition.

EXAMPLE X

A dust composition is prepared by admixing and pulverizing 3 parts ofone of the compounds numbered 2, 3, 4, 8, 9, 11, 16, 17, 22, 23, 26, 36,53 or 54 with 97 parts of Barden clay to obtain a composition containing3 percent of the active ingredient. In application, the composition isdusted as such.

EXAMPLE XI

50 Parts of one of the compounds numbered 35, 54 or 55; 5 parts of awetting agent (alkylbenzenesulfonate type) and 45 parts of diatomaceousearth are thoroughly pulverized and mixed together to obtain a wettablepowder containing 50 percent of active ingredient. In application, thepowder is diluted with water and used as a spray.

EXAMPLE XII

A mixture of 5 parts of one of the compounds numbered 2, 5, 7, 13, 43,44, 51, 54 or 55; 93.5 parts of clay and 1.5 parts of polyvinyl alcoholare thoroughly kneaded with water and the mixture granulated and dried.The granule composition contains 5 percent of the active ingredient andcan be applied as such.

EXAMPLE XIII

25 Parts of compound numbered 49, 50 parts of toluene and 25 parts ofAtlox 3404F^(R) (proprietary material of Imperial Chemical Industries,U.S. which is a polyoxyethylene alkyl aryl ether-alkyl aryl sulfonateblend) are mixed together to obtain an emulsifiable concentrate havingan active ingredient concentration of 25 percent. In application, theconcentrate is diluted with water and sprayed.

EXAMPLE XIV

7.6 Parts of one of the compounds numbered 17, 20, 46, 48, 50, 51 or 54;80.4 parts of purified material of Imperial Chemical Industries, U.S.which is a polyoxyethylene sorbitol ester) are mixed together to obtainan emulsifiable concentrate having an active ingredient concentration of7.6%. In application, the preparation is diluted with water and used asa spray.

EXAMPLE XV

1 Part of one of the compounds numbered 8, 11, 16, 37, 42 or 44 is mixedwith 99 parts of purified Kerosene to obtain an oil preparation havingan active ingredient concentration of 1 percent. In application, thecomposition can be atomized or sprayed as is.

The control of pest organisms by the contacting thereof with one or moreof the compounds of the present invention is illustrated by thefollowing examples.

EXAMPLE XVI

Cylindrical cages about 35/8 inches in diameter by 31/4 inches high werefitted with wire screen on the top and bottom. Into each cage was placeda predetermined number of German cockroaches. An aqueous dispersion,prepared by admixing one of the hereinafter set forth compounds with apredetermined amount of water and a surfactant, was sprayed on thecockroaches through the screen from a distance of about 15 inches. Atthe same time additional cockroaches were sprayed with awater-surfactant mixture containing no active toxicant to serve ascontrols. After spraying, the cockroaches were fed a sugar-water dietfor 3 days. At the end of this period, the cages were examined todetermine the minimum concentration in parts of active compound permillion parts of the ultimate composition (PPM) necessary to give atleast a 100 percent (LD₁₀₀) kill and control of the cockroaches. Theresults of this examination are set forth below in Table VIII.

                  TABLE VIII                                                      ______________________________________                                                         Minimum Concentration                                                         of Active Compound in                                        Compound Number of                                                                             PPM to give LD.sub.100 for                                   Active Compound  German Cockroaches                                           ______________________________________                                         1               25                                                           1A               50                                                           1B               25                                                            3               25                                                            4               400                                                           5               25                                                            6               25                                                           10               400                                                          12               25                                                           13               100                                                          14               25                                                           15               100                                                          24               25                                                           31               25                                                           Control          --                                                           ______________________________________                                    

EXAMPLE XVII

An aqueous dispersion was prepared by dispersing a predetermined amountof one of the test compounds and a predetermined amount of a surfactantin a predetermined amount of water. At the same time, a water/surfactantmixture containing none of the compounds was also prepared so serve as acontrol. Sheets containing egg masses of codling moths are pinned toapples and the egg sheets and apples are drenched with an aqueousdispersion of one of the hereinafter set forth compounds. Separate eggmasses on apples were also treated with the control mixture. The eggmasses/apples were incubated under conditions conducive to the hatchingof the eggs and the growth of the larvae therefrom. Ten days aftertreatment, the apples were examined for the presence of larvae. Countsof the number of larvae penetration in the treated fruit was compared tothe number present in the control to determine the present controlobtained with the test compounds.

This examination determined the minimum concentration in parts of theactive compound per million parts of the ultimate dispersion necessaryto give at least a 70 percent kill and control of codling moth larvaeand the results of this examination are set forth below in Table IX.

                  TABLE IX                                                        ______________________________________                                                       Minimum                                                                       Concentration in PPM                                                          of active compound                                             Number of      in aqueous dispersion                                          active         to give LD.sub.70 for                                          Compound       codling moth larvae                                            ______________________________________                                         1             25                                                              3             25                                                              5             25                                                              6             100                                                            10             100                                                            12             25                                                             13             25                                                             14             25                                                             15             25                                                             24             100                                                            32             400                                                            34             25                                                             36             25                                                             Control        --                                                             ______________________________________                                    

EXAMPLE XVIII

Seventy-five grams of air-dried soil was placed in an 8-ounce container.To the soil was added prepared by admixing a predetermined amount of oneof the hereinafter set forth compounds with a predetermined amount ofwater and a predetermined amount of a surfactant, to give variouspredetermined concentrations of the toxidant in the soil on asoil-chemical basis. The treated soil was air-dried and thoroughly mixedby agitation. To each treated container, and control containers treatedwith water and surfactant alone, was added 0.5 milliliters of an aqueoussuspension of the eggs of the Western spotted cucumber beetle (WSCB)(70-80 eggs of 3-4 days old). Additional treated soil was used to coverthe eggs and corn seed was placed on the soil and covered withadditional treated soil. The containers were thereafter maintained underconditions conducive to the growth of the seeds and the hatching of theeggs. Twelve (12) days after treatment, the containers and the plantstherein were examined to determine the minimum concentration in parts ofactive compound per million parts of the ultimate dispersion necessaryto give at least a 100 percent kill and control of the larvae from thehatched eggs. The results of this examination are set forth below inTable X.

                  TABLE X                                                         ______________________________________                                                       Minimum                                                                       Concentration in PPM                                           Number of      of active compound                                             active         in soil to give LD.sub.100                                     Compound       of WSCB larvae                                                 ______________________________________                                         1             6                                                               3             6                                                               5             6                                                              12             25                                                             13             6                                                              14             25                                                             24             25                                                             31             6                                                              32             6                                                              34             25                                                             36             1.5                                                            Control        --                                                             ______________________________________                                    

EXAMPLE XIX

In this operation, aqueous dispersions were prepared by admixing one ofthe hereinafter set forth compounds with a predetermined quantity ofwater and a predetermined amount of a surfactant to give aqueousdispersions containing varying predetermined amounts of one of thecompounds as the sole active toxicant. Separate cotton plant leaves werethoroughly wetted briefly with one of the dispersions and the wettedleaves placed in an open petri dish and permitted to dry. After theleaves were dry, 5 live beet armyworm larvae were placed in each Petridish. In identical operations, 5 live beet armyworm larvae were placedin control Petri dishes, the leaf therein having been wetted with asolution containing only water and surfactant. The dishes weremaintained under moist conditions conducive for the growth of the beetarmyworm larvae for a period of about 5 days. At the end of the 5-dayperiod, the dishes were examined to determine the minimum concentrationin parts of the active compound per million parts of the ultimatedispersion necessary to give at least a 100 percent kill and control ofthe beet armyworm larvae. The results of this examination are set forthbelow in Table XI.

                  TABLE XI                                                        ______________________________________                                                       MInimum                                                                       Concentration in PPM                                                          of active compound                                             Number of      in dispersion to                                               active         give LD.sub.100 for beet                                       Compound       armyworm larvae                                                ______________________________________                                         1             25                                                             1A             50                                                             1B             12.5                                                            3             25                                                              5             100                                                             6             100                                                            10             400                                                            12             25                                                             13             100                                                            14             100                                                            15             100                                                            18             100                                                            24             100                                                            31             25                                                             32             400                                                            34             100                                                            36             400                                                            Control        --                                                             ______________________________________                                    

EXAMPLE XX

In this operation, aqueous dispersions were prepared by admixing one ofthe hereinafter set forth compounds with a predetermined quantity ofwater and a predetermined amount of a surfactant to give aqueousdispersions of varying predetermined amounts of one of the compounds asthe sole active toxicant. Separate 3 inch discs cut from tobacco plantleaves were thoroughly wetted briefly with one of the dispersions andthe wetted leaves placed in an open Petri dish and permitted to dry.After the leaves were dry, 5 live tobacco budworm larvae were placed ineach Petri dish. In identical operations, 5 live tobacco budworm larvaewere placed in control Petri dishes, the leaf therein having been wettedwith a solution containing only water and surfactant. The dishes weremaintaned under moist conditions conducive for the growth of the tobaccobudworm larvae for a period of about 2 days. At the end of the 2-dayperiod, the dishes were examined to determine the minimum concentrationin parts of the active compound per million parts of the ultimatedispersion necessary to give at least a 100 percent kill and control ofthe tobacco budworm larvae. The results of this examination are setforth below in Table XII.

                  TABLE XII                                                       ______________________________________                                                       Minimum                                                                       Concentration in PPM                                                          of active compound                                             Number of      in dispersion to                                               active         give LD.sub.100 for to-                                        Compound       bacco budworm larvae                                           ______________________________________                                         1             25                                                             1A             3.1                                                            1B             12.5                                                            4             25                                                              5             100                                                             6             400                                                            10             100                                                            12             25                                                             13             100                                                            14             400                                                            15             400                                                            24             100                                                            29             400                                                            31             100                                                            32             100                                                            34             100                                                            36             25                                                             Control        --                                                             ______________________________________                                    

EXAMPLE XXI

Aqueous dispersions were prepared by admixing one of the hereinafter setforth compounds with a predetermined quantity of water and apredetermined amount of a surfactant to give aqueous dispersionscontaining varying predetermined amounts of one of the compounds as thesole toxicant. Separate rice plants were dipped into one of thedispersions and permitted to dry. A plastic cylinder was placed aroundthe plants and 10 adult Aster leafhoppers were placed in the cylinderand the cylinder capped. In a like manner, 10 adult Aster leafhopperswere placed on control plants which had been dipped in a solutioncontaining only water and surfactant. The plants were maintained underconditions conducive to the growth of the plants and leafhoppers. Aftera period of two days, the cylinder and plants were examined to determinethe minimum concentration in parts of the active compound per millionparts of the ultimate dispersion necessary to give at least 95 percentkill and control of the Aster leafhopper. The results of thisexamination are set forth below in Table XIII.

                  TABLE XIII                                                      ______________________________________                                                       Minimum                                                                       Concentration in PPM                                                          of active compound                                             Number of      in dispersion to                                               active         give LD.sub.95 for Aster                                       Compound       leafhoppers                                                    ______________________________________                                         1             12.5                                                           1A             12.5                                                           1B             12.5                                                            7             25                                                             15             100                                                            19             25                                                             27             100                                                            29             400                                                            36             25                                                             39             400                                                            41             400                                                            43             25                                                             48             400                                                            50             100                                                            Control        --                                                             ______________________________________                                    

EXAMPLE XXII

Aqueous dispersions were prepared by admixing one of the hereinafter setforth compounds with a predetermined quantity of water and apredetermined amount of a surfactant to give aqueous dispersionscontaining varying predetermined amounts of one of the compounds as thesole toxicant. Separate wild mustard plants were infested with 20 greenpeach aphids and the plants sprayed with one of the dispersions to runoff. In a like manner, 20 green peach aphids were placed on controlplants and the plants sprayed to run off with a solution containing onlywater and surfactant. The plants were maintained under conditionsconducive to the growth of the plants and aphids. After a period of twodays, the plants were examined to determine the minimum concentration inparts of the active compound per million parts of the ultimatedispersion necessary to give at least 100 percent kill and control ofthe green peach aphids. The results of this examination are set forthbelow in Table XIV.

                  TABLE XIV                                                       ______________________________________                                                       Minimum                                                                       Concentration in PPM                                                          of active compound                                             Number of      in dispersion to                                               active         give LD.sub.100 for green                                      Compound       peach aphid                                                    ______________________________________                                         1             3.1                                                            1B             1.5                                                             7             6.25                                                           12             6.25                                                           34             6.25                                                           Control        --                                                             ______________________________________                                    

EXAMPLE XXIII

Aqueous dispersions were prepared by admixing one of the hereinafter setforth compounds with a predetermined quantity of water and apredetermined amount of a surfactant to give aqueous dispersionscontaining varying predetermined amounts of one of the compounds as thesole toxicant. Separate groups of 5 adult carpet beetles (Trogodermaversicolor) were placed on filter paper in a Petri dish and were sprayedwith 1 milliliter of one of the test dispersions. At the same time,additional dishes containing 5 adult carpet beetles were sprayed with awater/surfactant mixture containing none of the compounds. The disheswere maintained under conditions conducive to the growth of the beetles.After a period of 24 hours, the Petri dishes were examined to determinethe minimum concentration in parts of the active compound per millionparts of the ultimate dispersion necessary to give at least 100 percentkill and control of the carpet beetles. The results of this examinationare set forth below in Table XV.

                  TABLE XV                                                        ______________________________________                                                       Minimum                                                                       Concentration in PMM                                                          of active compound                                             Number of      in dispersion to                                               active         give LD.sub.100 for                                            Compound       carpet beetles                                                 ______________________________________                                         1             6.2                                                            1B             6.2                                                             7             3.1                                                            12             12.5                                                           34             25                                                             Control        --                                                             ______________________________________                                    

What is claimed is:
 1. A compound corresponding to the formula ##STR28##wherein X independently represents alkyl of 1 to 4 carbon atoms, alkoxyof 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkylsulfonylof 1 to 4 carbon atoms, trifluoromethyl, 3,4-methylenedioxy, chloro,fluoro or bromo; n represents an integer of 0 to 2; Y represents oxygenor sulfur; R represents hydrogen, cyano or ethynyl and Z representschloro, fluoro or bromo.
 2. A compound as defined in claim 1 wherein Yis oxygen.
 3. A compound as defined in claim 1 wherein Z is chloro.
 4. Acompound as defined in claim 1 wherein R is cyano.
 5. A compound asdefined in claim 2 wherein R is cyano.
 6. A compound as defined in claim5 wherein Z is chloro.
 7. A compound as defined in claim 6 wherein n is0.
 8. The compound as defined in claim 7 which is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 9. The compound asdefined in claim 7 which iscis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 10. The compound asdefined in claim 7 which istrans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 11. A compound as definedin claim 6 wherein n is
 1. 12. The compound as defined in claim 11 whichis 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-methoxyphenoxy)-2-pyridinyl)-methyl ester.
 13. Thecompound as defined in claim 11 which is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-chlorophenoxy)-2-pyridinyl)methyl ester.
 14. Thecompound as defined in claim 11 which is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(3-fluorophenoxy)-2-pyridinyl)methyl ester.
 15. Thecompound as defined in claim 11 which is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-fluorophenoxy)-2-pyridinyl)methyl ester.
 16. Aninsecticidal composition comprising as the active ingredient, aninsecticidally effective amount of a compound corresponding to theformula ##STR29## wherein X independently represents alkyl of 1 to 4carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbonatoms, alkylsulfonyl of 1 to 4 carbon atoms, trifluoromethyl,3,4-methylenedioxy, chloro, fluoro or bromo; n represents an integer of0 to 2; Y represents oxygen or sulfur; R represents hydrogen, cyano orethynyl and Z represents chloro, fluoro or bromo, in intimate admixturewith an inert carrier therefor.
 17. A composition as defined in claim 16wherein Y is oxygen.
 18. A composition as defined in claim 16 wherein Zis chloro.
 19. A composition as defined in claim 16 wherein R is cyano.20. A composition as defined in claim 17 wherein R is cyano.
 21. Acomposition as defined in claim 20 wherein Z is chloro.
 22. Acomposition as defined in claim 21 wherein n is
 0. 23. The compositionas defined in claim 22 wherein the compound is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 24. The composition asdefined in claim 22 wherein the compound iscis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxlicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 25. The composition asdefined in claim 22 wherein the compound istrans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 26. A composition asdefined in claim 21 wherein n is
 1. 27. The composition as defined inclaim 26 wherein the compound is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-methoxyphenoxy)-2-pyridinyl)methyl ester.
 28. Thecomposition as defined in claim 26 wherein the compound is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-chlorophenoxy)-2-pyridinyl)methyl ester.
 29. Thecomposition as defined in claim 26 wherein the compound is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(3-fluorophenoxy)-2-pyridinyl)methyl ester.
 30. Thecomposition as defined in claim 26 wherein the compound is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-fluorophenoxy)-2-pyridinyl)methyl ester.
 31. A methodfor the kill and control of insects which comprises contacting saidinsects or their habitat with a composition containing as the activeingredient, an insecticidally effective amount of a compoundcorresponding to the formula ##STR30## wherein X independentlyrepresents alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,alkylthio of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms,trifluoromethyl, 3,4-methylenedioxy, chloro, fluoro or bromo; nrepresents an integer of 0 to 2; Y represents oxygen or sulfur; Rrepresents hydrogen, cyano or ethynyl and Z represents chloro, fluoro orbromo, in intimate admixture with an inert carrier therefor.
 32. Amethod as defined in claim 31 wherein Y is oxygen.
 33. A method asdefined in claim 31 wherein Z is chloro.
 34. A method as defined inclaim 31 wherein R is cyano.
 35. A method as defined in claim 32 whereinR is cyano.
 36. A method as defined in claim 35 wherein Z is chloro. 37.A method as defined in claim 36 wherein n is
 0. 38. The method asdefined in claim 37 wherein the active ingredient is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 39. The method as definedin claim 37 wherein the active ingredient iscis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 40. The method as definedin claim 37 wherein the active ingredient istrans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-phenoxy-2-pyridinyl)methyl ester.
 41. A method as definedin claim 36 wherein n is
 1. 42. The method as defined in claim 41wherein the active ingredient is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-methoxyphenoxy)-2-pyridinyl)methyl ester.
 43. The methodas defined in claim 41 wherein the active ingredient is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-chlorophenoxy)-2-pyridinyl)methyl ester.
 44. The methodas defined in claim 41 wherein the active ingredient is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(3-fluorophenoxy)-2-pyridinyl)methyl ester.
 45. The methodas defined in claim 41 wherein the active ingredient is3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylicacid:cyano(6-(4-fluorophenoxy)-2-pyridinyl)methyl ester.